[Top] [Lecturers]
[Program] [Purpose]
[Schedule] [Links]
INTERNATIONAL SCHOOL OF STRUCTURAL
BIOLOGY AND MAGNETIC RESONANCE
5th Course:
PROTEIN STRUCTURE, DYNAMICS,
GENOMICS AND FUNCTION
|
ERICE-SICILY: 5-15 JUNE 2001
Ettore Majorana Foundation
and Centre for Scientific Culture
|
A NATO Advance Study Institute
DIRECTOR OF THE SCHOOL:
Oleg Jardetzky:
jardetzky@stanford.edu
(Molecular
Pharmacology,
Stanford University)
DIRECTORS OF THE COURSE:
Dino Moras:
moras@titus.u-strasbg.fr
(Laboratoire de Biologie et Genomique
Structurales,
IGBMC)
Jacek Hennel:
jacek.hennel@inetia.pl
(The Henryk NiewodniczaÄski Institute of Nuclear Physics in Cracow)
REGISTRAR:
Manolia Margaris:
manolia@stanford.edu
(SMRL,
Puglisi group,
Stanford University)
SPONSORED BY:
The Italian Ministry of Education
The Italian Ministry of University and Scientific-Technological
Research
The Sicilian Regional Government
(Additional information will be added as it becomes available.)
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[Program] [Purpose]
[Schedule] [Links]
LECTURERS:
- IVANO BERTINI, Universita degli Studi di Firenze, Italy
- ANGELA GRONENBORN, National Institutes of Health, USA
- CORNELIUS W. HILBERS, University of Nijmegen, The Netherlands
- OLEG JARDETZKY, Stanford University, USA
- PATRICE KOEHL, Stanford University, USA
- WILLIAM N. LIPSCOMB, Harvard University, USA
- JOHN L. MARKLEY, University of Wisconsin, USA
- DINO MORAS, Universite Louis Pasteur, France
- ALBERTO PODJARNY, CNRS, France
- JOSEPH D. PUGLISI, Stanford University, USA
- GORDON C. K. ROBERTS, University of Leicester, UK
- BRIAN D. SYKES, University of Alberta, Canada
- MICHELE BENDRUSCOLO, Oxford Centre for Molecular Sciences, Oxford, UK
- GERHARD WAGNER, Harvard Medical School, USA
- DON WILEY, Harvard University, USA
- MARAT YUSUPOV, Universite Louis Pasteur, France
[Top] [Lecturers]
[Program] [Purpose]
[Schedule] [Links]
PROGRAM:
Modern Techniques for the study of protein structure and dynamics:
X-ray Crystallography
High Resolution NMR
Molecular Dynamics
Genomic analysis of protein structure and function
Specific topics:
Dynamics and conformational transitions in allosteric proteins
The energy landscape of proteins
Simulations of protein folding
Predictions of protein structure
Models of drug-receptor interactions
Signaling proteins
Nucleic acid structure and dynamics
RNA as a drug receptor
Protein-DNA complexes, heteronuclear strategies for the assignment of larger
complexes
[Top] [Lecturers]
[Program] [Purpose]
[Schedule] [Links]
PURPOSE OF THE COURSE:
The focus of the school will be on the type of information that can be obtained
about dynamic processes in protein by NMR, crystallography and other physical
methods and the implications for protein and drug design. The current and advanced
status in the field of dynamics and structural studies of proteins and nucleic
acids will be reviewed.
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[Program] [Purpose]
[Schedule] [Links]
FINAL SCHEDULE: (As Of May 31, 2001)
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[Tue-5] [Wed-6]
[Thu-7] [Fri-8]
[Sat-9] [Sun-10]
[Mon-11] [Tue-12]
[Wed-13] [Thu-14]
[Fri-15]
Tuesday, June 5, 2001
[Top]
[Tue-5] [Wed-6]
[Thu-7] [Fri-8]
[Sat-9] [Sun-10]
[Mon-11] [Tue-12]
[Wed-13] [Thu-14]
[Fri-15]
Wednesday, June 6
9:00-10:00 |
Oleg Jardetzky - Overview of the course |
10:00-11:00 |
Cornelius Hilbers - Principles of NMR and Dynamics |
11:00-11:30 |
Coffee break |
11:30-12:30 |
Alberto Podjarny - Introduction to X-ray Crystallography |
12:30-15:00 |
Lunch |
15:00-16:00 |
Michele Vendruscolo - Protein folding and energy minimization |
16:00-17:30 |
Workshop - X-ray diffraction - Drs. Podjarny and Lipscomb |
17:30-18:30 |
Workshop - Principles of NMR - Drs. Hilbers and Jardetzky |
[Top]
[Tue-5] [Wed-6]
[Thu-7] [Fri-8]
[Sat-9] [Sun-10]
[Mon-11] [Tue-12]
[Wed-13] [Thu-14]
[Fri-15]
Thursday, June 7
9:00-10:00 |
Jody Puglisi - RNA Structure by NMR |
10:00-11:00 |
Gordon Roberts - Protein Structure Determination by NMR |
11:00-11:30 |
Coffee break |
11:30-12:30 |
Don Wiley - The structure and function of the T-cell receptor |
12:30-15:00 |
Lunch |
15:00-16:00 |
John Markley - Derivation of thermodynamic quantities from NMR data |
16:30-18:00 |
Workshop - The meaning of protein structures - Drs. Wiley and Roberts |
[Top]
[Tue-5] [Wed-6]
[Thu-7] [Fri-8]
[Sat-9] [Sun-10]
[Mon-11] [Tue-12]
[Wed-13] [Thu-14]
[Fri-15]
Friday, June 8
9:00-10:00 |
Don Wiley - The activity of membrane glycoproteins of Influenza,
HIV-1 and Ebola viruses during cellular entry |
10:00-11:00 |
Gordon Roberts - Protein Signaling and Interaction |
11:00-11:30 |
Coffee break |
11:30-12:30 |
John Markley - NMR approaches to the investigation of hydrogen bonding in biomolecules |
12:30-15:00 |
Lunch |
15:00-16:00 |
Michele Vendruscolo - Structural determination of partially folded states of proteins from residue-specific experimental data |
16:00-18:00 |
Workshop - NMR methodology - Dr. Markley |
[Top]
[Tue-5] [Wed-6]
[Thu-7] [Fri-8]
[Sat-9] [Sun-10]
[Mon-11] [Tue-12]
[Wed-13] [Thu-14]
[Fri-15]
Saturday, June 9
9:00 -10:00 |
Angela Gronenborn - Assignment Strategies for larger proteins |
10:00-11:00 |
Cornelius Hilbers - Nucleic Structure and Dynamics |
11:00-11:30 |
Coffee break |
11:30-12:30 |
Joseph Puglisi - Principles of RNA Structure |
12:30-15:00 |
Lunch |
15:00-16:00 |
Alberto Podjarny - From low to ultra high resolution |
16:00-18:00 |
Workshop - NMR of Nucleic Acids - Drs. Hilbers and
Puglisi |
[Top]
[Tue-5] [Wed-6]
[Thu-7] [Fri-8]
[Sat-9] [Sun-10]
[Mon-11] [Tue-12]
[Wed-13] [Thu-14]
[Fri-15]
Sunday, June 10
9:00-19:00 |
All Day Excursion |
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[Tue-5] [Wed-6]
[Thu-7] [Fri-8]
[Sat-9] [Sun-10]
[Mon-11] [Tue-12]
[Wed-13] [Thu-14]
[Fri-15]
Monday, June 11
9:00-10:00 |
Patrice Koehl - Molecular Dynamics and Molecular Modeling |
10:00-11:00 |
Brian Sykes - Sidechain Dynamics and Protein Signaling |
11:00-11:30 |
Coffee break |
11:30-12:30 |
Marat Yusupov - Structure of the 70S ribosome from thermus
thermophilus: Part I: Structure description |
12:30-15:00 |
Lunch |
15:00-16:00 |
Marat Yusupov - Structure of the 70S ribosome from thermus
thermophilus: Part II: Crystallization and structure determination |
16:00-17:00 |
Workshop - Protein dynamics - Drs. Sykes and Gronenborn |
17:30-18:00 |
Workshop - Structure of the ribosome - Drs. Yusupov and Puglisi |
[Top]
[Tue-5] [Wed-6]
[Thu-7] [Fri-8]
[Sat-9] [Sun-10]
[Mon-11] [Tue-12]
[Wed-13] [Thu-14]
[Fri-15]
Tuesday, June 12
9:00-10:00 |
Angela Gronenborn - Complex Protein Structures |
10:00-11:00 |
William N Lipscomb - Allosteric Proteins |
11:00-11:30 |
Coffee break |
11:30-12:30 |
Patrice Koehl - Can we predict the sequence of a protein? |
12:30-15:00 |
Lunch |
15:00-16:30 |
Student Symposium I |
16:30-18:00 |
Poster Session I |
[Top]
[Tue-5] [Wed-6]
[Thu-7] [Fri-8]
[Sat-9] [Sun-10]
[Mon-11] [Tue-12]
[Wed-13] [Thu-14]
[Fri-15]
Wednesday, June 13
9:00-10:00 |
Dino Moras - Nuclear Receptors |
10:00-11:00 |
Gerhard Wagner - How can we trick proteins to behave well for NMR studies? |
11:00-11:30 |
Coffee break |
11:30-12:30 |
Ivano Bertini - Solution Structures of Metalloproteins |
12:30-15:00 |
Lunch |
15:00-16:00 |
Workshop - Simulations and Calculations- Dr. Koehl |
16:30-18:00 |
Workshop - Proteins and Nucleic Acids - Drs. Moras and Puglisi |
[Top]
[Tue-5] [Wed-6]
[Thu-7] [Fri-8]
[Sat-9] [Sun-10]
[Mon-11] [Tue-12]
[Wed-13] [Thu-14]
[Fri-15]
Thursday, June 14
9:00-10:00 |
Dino Moras - Mapping the Pathways of Allosteric Control |
10:00-11:00 |
Gerhard Wagner - Studies of protein interactions in translation initiation and apoptosis |
11:00-11:30 |
Coffee break |
11:30-12:30 |
Brian Sykes - Water in Protein Interactions |
12:30-15:00 |
Lunch |
15:00-16:00 |
Workshop - Protein Dynamics and Interactions - Dr. Wagner |
16:00-18:00 |
Poster Session II |
[Top]
[Tue-5] [Wed-6]
[Thu-7] [Fri-8]
[Sat-9] [Sun-10]
[Mon-11] [Tue-12]
[Wed-13] [Thu-14]
[Fri-15]
Friday, June 15
9:00-12:00 |
Round Table - Problems remaining to be Solved
Moderators: Drs. Moras and Jardetzky
Panel: All lecturers |
12:00 |
Departure |
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[Tue-5] [Wed-6]
[Thu-7] [Fri-8]
[Sat-9] [Sun-10]
[Mon-11] [Tue-12]
[Wed-13] [Thu-14]
[Fri-15]
[Top] [Lecturers]
[Program] [Purpose]
[Schedule] [Links]
LINKS:
[Top] [Lecturers]
[Program] [Purpose]
[Schedule] [Links]
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