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INTERNATIONAL SCHOOL OF STRUCTURAL
BIOLOGY AND MAGNETIC RESONANCE

5th Course:
PROTEIN STRUCTURE, DYNAMICS,
GENOMICS AND FUNCTION

EMFCSC logo ERICE-SICILY: 5-15 JUNE 2001
Ettore Majorana Foundation
and Centre for Scientific Culture

A NATO Advance Study Institute

DIRECTOR OF THE SCHOOL:
Oleg Jardetzky:
jardetzky@stanford.edu
(Molecular Pharmacology, Stanford University)

DIRECTORS OF THE COURSE:
Dino Moras: moras@titus.u-strasbg.fr
(Laboratoire de Biologie et Genomique Structurales, IGBMC)
Jacek Hennel: jacek.hennel@inetia.pl
(The Henryk Niewodniczański Institute of Nuclear Physics in Cracow)

REGISTRAR:
Manolia Margaris: manolia@stanford.edu
(SMRL, Puglisi group, Stanford University)

SPONSORED BY:
The Italian Ministry of Education
The Italian Ministry of University and Scientific-Technological Research
The Sicilian Regional Government

(Additional information will be added as it becomes available.)


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LECTURERS:


[Top] [Lecturers] [Program] [Purpose] [Travel Info] [Schedule] [Links]

PROGRAM:

Modern Techniques for the study of protein structure and dynamics:

X-ray Crystallography
High Resolution NMR
Molecular Dynamics
Genomic analysis of protein structure and function

Specific topics:

Dynamics and conformational transitions in allosteric proteins
The energy landscape of proteins
Simulations of protein folding
Predictions of protein structure
Models of drug-receptor interactions
Signaling proteins
Nucleic acid structure and dynamics
RNA as a drug receptor
Protein-DNA complexes, heteronuclear strategies for the assignment of larger complexes


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PURPOSE OF THE COURSE:

The focus of the school will be on the type of information that can be obtained about dynamic processes in protein by NMR, crystallography and other physical methods and the implications for protein and drug design. The current and advanced status in the field of dynamics and structural studies of proteins and nucleic acids will be reviewed.


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FINAL SCHEDULE: (As Of May 31, 2001)

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Tuesday, June 5, 2001
  Arrivals
19:00 Mixer

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Wednesday, June 6
9:00-10:00 Oleg Jardetzky - Overview of the course
10:00-11:00 Cornelius Hilbers - Principles of NMR and Dynamics
11:00-11:30 Coffee break
11:30-12:30 Alberto Podjarny - Introduction to X-ray Crystallography
12:30-15:00 Lunch
15:00-16:00 Michele Vendruscolo - Protein folding and energy minimization
16:00-17:30 Workshop - X-ray diffraction - Drs. Podjarny and Lipscomb
17:30-18:30 Workshop - Principles of NMR - Drs. Hilbers and Jardetzky

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Thursday, June 7
9:00-10:00 Jody Puglisi - RNA Structure by NMR
10:00-11:00 Gordon Roberts - Protein Structure Determination by NMR
11:00-11:30 Coffee break
11:30-12:30 Don Wiley - The structure and function of the T-cell receptor
12:30-15:00 Lunch
15:00-16:00 John Markley - Derivation of thermodynamic quantities from NMR data
16:30-18:00 Workshop - The meaning of protein structures - Drs. Wiley and Roberts

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Friday, June 8
9:00-10:00 Don Wiley - The activity of membrane glycoproteins of Influenza, HIV-1 and Ebola viruses during cellular entry
10:00-11:00 Gordon Roberts - Protein Signaling and Interaction
11:00-11:30 Coffee break
11:30-12:30 John Markley - NMR approaches to the investigation of hydrogen bonding in biomolecules
12:30-15:00 Lunch
15:00-16:00 Michele Vendruscolo - Structural determination of partially folded states of proteins from residue-specific experimental data
16:00-18:00 Workshop - NMR methodology - Dr. Markley

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Saturday, June 9
9:00 -10:00 Angela Gronenborn - Assignment Strategies for larger proteins
10:00-11:00 Cornelius Hilbers - Nucleic Structure and Dynamics
11:00-11:30 Coffee break
11:30-12:30 Joseph Puglisi - Principles of RNA Structure
12:30-15:00 Lunch
15:00-16:00 Alberto Podjarny - From low to ultra high resolution
16:00-18:00 Workshop - NMR of Nucleic Acids - Drs. Hilbers and Puglisi

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Sunday, June 10
9:00-19:00 All Day Excursion

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Monday, June 11
9:00-10:00 Patrice Koehl - Molecular Dynamics and Molecular Modeling
10:00-11:00 Brian Sykes - Sidechain Dynamics and Protein Signaling
11:00-11:30 Coffee break
11:30-12:30 Marat Yusupov - Structure of the 70S ribosome from thermus thermophilus:
Part I: Structure description
12:30-15:00 Lunch
15:00-16:00 Marat Yusupov - Structure of the 70S ribosome from thermus thermophilus:
Part II: Crystallization and structure determination
16:00-17:00 Workshop - Protein dynamics - Drs. Sykes and Gronenborn
17:30-18:00 Workshop - Structure of the ribosome - Drs. Yusupov and Puglisi

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Tuesday, June 12
9:00-10:00 Angela Gronenborn - Complex Protein Structures
10:00-11:00 William N Lipscomb - Allosteric Proteins
11:00-11:30 Coffee break
11:30-12:30 Patrice Koehl - Can we predict the sequence of a protein?
12:30-15:00 Lunch
15:00-16:30 Student Symposium I
16:30-18:00 Poster Session I

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Wednesday, June 13
9:00-10:00 Dino Moras - Nuclear Receptors
10:00-11:00 Gerhard Wagner - How can we trick proteins to behave well for NMR studies?
11:00-11:30 Coffee break
11:30-12:30 Ivano Bertini - Solution Structures of Metalloproteins
12:30-15:00 Lunch
15:00-16:00 Workshop - Simulations and Calculations- Dr. Koehl
16:30-18:00 Workshop - Proteins and Nucleic Acids - Drs. Moras and Puglisi

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Thursday, June 14
9:00-10:00 Dino Moras - Mapping the Pathways of Allosteric Control
10:00-11:00 Gerhard Wagner - Studies of protein interactions in translation initiation and apoptosis
11:00-11:30 Coffee break
11:30-12:30 Brian Sykes - Water in Protein Interactions
12:30-15:00 Lunch
15:00-16:00 Workshop - Protein Dynamics and Interactions - Dr. Wagner
16:00-18:00 Poster Session II

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Friday, June 15
9:00-12:00 Round Table - Problems remaining to be Solved
Moderators: Drs. Moras and Jardetzky
Panel: All lecturers
12:00 Departure

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[Top] [Lecturers] [Program] [Purpose] [Travel Info] [Schedule] [Links]

LINKS:


[Top] [Lecturers] [Program] [Purpose] [Travel Info] [Schedule] [Links]


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