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INTERNATIONAL SCHOOL OF STRUCTURAL
BIOLOGY AND MAGNETIC RESONANCE
6th Course:
STRUCTURE, DYNAMICS AND FUNCTION
OF BIOLOGICAL MACROMOLECULES AND ASSEMBLIES
A NATO Advanced Study Institute
DIRECTORS OF THE COURSE:
Jody Puglisi:
Puglisi@Stanford.Edu
Puglisi Group,
SMRL,
Structural
Biology,
Stanford University
(All correspondences should be directed to Prof. Puglisi)
Narcyz Pislewski:
Narcyz.Pislewski@ifmpa
n.poznan.pl
Institute of
Molecular Physics, Polish Academy of Sciences
REGISTRAR:
Manolia Margaris:
Manolia@Stanford.Edu
SMRL,
Puglisi Group,
Stanford University
DIRECTOR OF THE SCHOOL:
Oleg Jardetzky:
Molecular
Pharmacology,
Stanford University
DIRECTOR OF THE CENTRE:
Antonino
Zichichi
SPONSORED BY:
The Italian Ministry
of Education
The Italian Ministry of
University and Scientific-Technological Research
The Sicilian Regional Government
PURPOSE OF THE COURSE:
The school will teach the principles of biomolecular structure
determination by crystallography and NMR, and how dynamics
measurements are made and computed on biological systems. The
integration of other biophysical methods for the study
of dynamics will also be stressed.
Modern Techniques for the study of structure, dynamics and
function of biological macromolecules and assemblies:
NMR Spectroscopy
X-ray Crystallography
Molecular Dynamics
Macromolecular Function and Design
Single-molecule fluorescence
Specific topics:
Principles of NMR
Optical Spectroscopy
Principles of X-ray Crystallography
Nucleic acids and protein complexes
NMR Physics
Novel methods for structure determination of proteins and complexes
Protein-nucleic acid complexes
Single-molecule methods
Drug design
Large RNA NMR
Molecular dynamics simulations
Protein design and folding
Molecular recognition
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