SCHOOL PURPOSE

This Advanced Study Institute will cover structural and dynamic studies of proteins, relating them to protein function and the possibilities of protein design. Methods for the study of protein structure and dynamics continue to evolve and increase in accuracy and precision, with a resultant increase in the understanding of protein function. Our Course will integrate structure and dynamic information that has been obtained by different methods and provide a perspective on the major research questions in structural biology. Our aim is to provide the student with a critical appreciation of the principal methods that can be brought to bear on problems of protein structure, dynamics and function. The basic principles of these methods of study of protein structure and dynamics - x-ray diffraction, NMR, molecular dynamics and molecular modeling - will first be given in a series of introductory lectures. Additional presentations will focus on specific examples of protein structure determination, experimental and theoretical studies of protein dynamics by different methods, protein-ligand interactions, structure-function relations in proteins, and protein and protein analog design.

PROGRAM